Protects and Helps Maintain Balance, Bioavailability and Safety of Naturally Produced Hormones as well as Hormonal Therapies Hormone Balance & Protect is a nutritional and herbal formula critical to supporting healthy and safe metabolism of endogenous hormones as well as hormonal therapies. Optimal endocrine function requires both sufficient hormone production and availability, as well as highly functioning hormone receptors. Widespread exposure to endocrine disrupting compounds (EDCs) interferes with many hormone-dependent processes in what should be a closely controlled communications system, partly by competing at hormone and nuclear receptors, and mimicking or suppressing endogenous hormone activity.1 This formula provides key nutrients and botanicals to help stabilize hormone levels and enhance their binding, restoring balance to hormonal signaling pathways. Hormone Balance & Protect formulator, Dr. Devaki Lindsey Berkson, has worked as a hormone scholar at a Tulane University estrogen think-tank (Center for Bioenvironmental Research) with scientists who discovered the first two estrogen receptors, Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERß). Her focus on receptor function and not just hormone levels is partly a result of many lectures delivered over years of E.Hormone conferences, which highlighted the role of receptor functionality in keeping hormone signals intact, and the role of receptor function in disease prevention. Clinical Relevance Exposure to EDCs has become nearly universal, with many of their detrimental consequences mediated via hormonal interference. Although EDCs have diverse mechanisms of toxicity, they are known to interfere with the synthesis, action, and metabolism of sex steroid hormones, including direct interference at the steroid hormone receptor, such as the estrogen and androgen receptors.2 Phthalates, for example, interrupt testosterone synthesis in Leydig cells and may also modulate conversion to the more potent androgen dihydrotestosterone.3 Dioxins and certain organochlorine pesticides induce the activity of cytochrome P450 enzymes which metabolize estrogen more rapidly, decreasing the amount of estrogen available for binding.4 Hormone Balance & Protect Benefits: • Protects and helps maintain balance, bioavailability and safety of naturally produced hormones as well as prescribed hormonal therapies. • Promotes hormone balance by enhancing bioavailability of hormone action on diverse cells. • Supports overall balanced and hormonal health including receptor functionality, optimal duration of signaling time and nutrient support for transcriptional co-factors to get critical hormone signals into cell’s genes.